Novak Djokovic is out of Wimbledon after a shock defeat by American Sam Querrey – ending the world number one’s hopes of a calendar-year Grand Slam.

Querrey, seeded 28th, completed a 7-6 (8-6) 6-1 3-6 7-6 (7-5) third-round win after rain had suspended play on Friday evening.

It was the Serb’s first loss at a major since the 2015 French Open final.

Britain’s Andy Murray, seeded second, made it into round four with a 6-3 7-5 6-2 win over Australia’s John Millman.

Djokovic had hoped to win his third straight Wimbledon title and secure the third leg of a calendar Slam.

The 29-year-old has already won the Australian and French Opens this year, and was also trying to become only the second man to win five successive major titles.

Asked whether he was 100% healthy, Djokovic said: “Not really. But it’s not the place and time to talk about it. The opponent was playing on a very high level and he deserved to win.”

Querrey ‘ecstatic’ with surprise win

“It’s incredible, especially to do it here at Wimbledon,” said 28-year-old Querrey after ending one of the most dominant runs in tennis history.

“I’m so ecstatic, so happy. I played the break points well and every time he had a break point I was able to come up with a big serve.

“He came out and got the first four games, fortunately for me we had another rain delay and I got to regroup. I’m just taking it one round at a time, I’m not even sure who I'm playing next.”

•Excerpted from a BBC report. Photo shows giant killer Sam Querrey.